Institution Address:

Center of Lipid Research

Chongqing Medical University

No.1 Yixueyuan Rd, Yuzhong District

Chongqing, 400016, China

Contact Information:

Tel: 86-23-68802030

Fax: 86-23-68486780

Email: chenyaxi@cqmu.edu.cn

Web: https://lipid.cqmu.edu.cn/

Education:

2004.9–2007.7   Ph.D., Internal medicine, Chongqing Medical University

1990.9–1993.7   M.M. (Master of Medicine), Internal medicine, Chongqing Medical University

1985.9–1990.7   B.Sc, Clinical medicine, Chongqing Medical University

Academic Appointments:

1993.7-present   Lecturer – Professor, Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University

2006.4-present   Professor, Centre for Lipid Research & Key Laboratory of Molecular Biology for infectious Diseases (Ministry of Education), Chongqing Medical University

2005.8-2006.8   Visiting scholar, Lipid Research Unit, Centre for Nephrology, Royal Free Hospital, UCL Medical School, London, UK

Grants:

2022-2025  as Principal Investigator, “The activation of Notch signaling mediated by cholesterol sensor SCAP under inflammation and the development of nonalcoholic fatty liver fibrosis”, National Natural Science Foundation of China (NSFC 82170586)

2019 -2022 as Principal Investigator, “Palmitoylation regulates fatty acid oxidation of mitochondria in hepatocytes mediated by FAT/CD36: a new mechanism for nonalcoholic fatty liver disease”, National Natural Science Foundation of China (NSFC 81873569)

2016-2019  as Principal Investigator, “Palmitoylation regulates FAT/CD36 subcellular localization and function: a novel mechanism of nonalcoholic fatty liver disease”, National Natural Science Foundation of China (NSFC 81570517)

2013-2016 as Principal Investigator,   “FAT/CD36 pathway mediated metabolic inflammation in liver and non-alcoholic fatty liver disease”, National Natural Science Foundation of China (NSFC 81270493)

2011-2013  as Principal Investigator,   “mTOR mediated abnormal phosphorylation of IRS under inflammation -- a potential molecular mechanism of insulin resistance”, National Natural Science Foundation of China (NSFC 81070631)

2010-2013   as Principal Investigator,   “Abnormal mTOR/S6K signaling pathway in inflammatory state: a new mechanism of insulin resistance”, National Natural Science Foundation of China (NSFC 30971389)

2009-2011   as Principal Investigator,   “Inflammation interfered with nuclear transcription factor SREBPs and caused the disorder of lipid metabolism in hepatocytes”, National Natural Science Foundation of China (NSFC 30871159)

Selected Publications:

1. Luo X#, Zhao Y#, Cai Y, Chen J, Zhao L, Lan T, Chen Y*, Ruan XZ*. Dual-monomer solvatochromic probe system (DSPS) for effectively differentiating lipid raft cholesterol and active membrane cholesterol in the inner-leaflet plasma membrane. J Mater Chem B. 2024 Mar 6;12(10):2547-2558. .  

2. Zheng G#, Su Y#, Wei L#, Yao Y, Wang Y, Luo X, Wang X, Ruan XZ, Li D*, Chen Y*. SCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice. Cell Death Dis. 2023 Apr 6;14(4):249.

3. Li Y#, Xu J#, Chen W#, Wang X#, Zhao Z, Li Y, Zhang L, Jiao J, Yang Q, Ding Q, Yang P, Wei L, Chen Y*, Chen Y*, Ruan XZ*, Zhao L*. Hepatocyte CD36 modulates UBQLN1-mediated proteasomal degradation of autophagic SNARE proteins contributing to septic liver injury. Autophagy 2023 Apr 4. doi: 10.1080/15548627.2023.2196876.

4. Li Y#, Wang T#, Liao Q#, Luo X, Wang X, Zeng S, You M, Chen Y*, Ruan XZ*. Loss of Splicing Factor SRSF3 Impairs Lipophagy through Ubiquitination and Degradation of Syntaxin17 in Hepatocytes. J Lipid Res. 2023 Feb 8;100342.

5. You M, Wu F, Gao M, Chen M, Zeng S, Zhang Y, Zhao W, Li D, Wei L, Ruan XZ*, Chen Y*. Selenoprotein K contributes to CD36 subcellular trafficking in hepatocytes by accelerating nascent COPII vesicle formation and aggravates hepatic steatosis. Redox Biol. 2022 Oct 7;57:102500.

6. Yang P, Qin H, Li Y, Xiao A, Zheng E, Zeng H, Su C, Luo X, Lu Q, Liao M, Zhao L, Wei L, Varghese Z, Moorhead JF, Chen Y*, Ruan XZ*. CD36-mediated metabolic crosstalk between tumor cells and macrophages affects liver metastasis. Nat Commun . 2022 Oct 2;13(1):5782.

7. Huang X#, Yao Y#, Hou X#, Wei L, Rao Y, Su Y, Zheng G, Ruan XZ, Li D*, Chen Y*. Macrophage SCAP contributes to metaflammation and lean NAFLD by activating STING-NF-κB signaling pathway. Cell Mol Gastroenterol Hepatol. 2022 Mar 31;14(1):1-26.  

8. Li D#, Yao Y#, Rao Y, Huang X, Wei L, You Z, Zheng G, Hou X, Su Y, Varghese Z, Moorhead JF, Chen Y*, Ruan XZ*. Cholesterol sensor SCAP contributes to sorafenib resistance by regulating autophagy in hepatocellular carcinoma. J Exp Clin Cancer Res. 2022 Mar 30;41(1):116.  

9. Zeng S#, Wu F#, Chen M#, Li Y, You M, Zhang Y, Yang P, Wei L, Ruan XZ, Zhao L*, Chen Y*. Inhibition of fatty acid translocase (FAT/CD36) palmitoylation enhances hepatic fatty acid β-oxidation by increasing its localization to mitochondria and interaction with long-chain acyl-CoA synthetase 1. Antioxid Redox Signal. 2022 Jun;36(16-18):1081-1100.

10. Zeng H#, Qin H#, Liao M, Zheng E, Luo X, Xiao A, Li Y, Chen L, Wei L, Zhao L, Ruan XZ, Yang P*, Chen Y*. CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing. Mol Metab. 2022 Mar;57:101428.

11. Li D#, Liu M#, Li Z, Zheng G, Chen A, Zhao L, Yang P, Wei L, Chen Y*, Ruan XZ*. Sterol-resistant SCAP overexpression in vascular smooth muscle cells accelerates atherosclerosis by increasing local vascular inflammation through activation of the NLRP3 inflammasome in mice. Aging and disease. 2021 Jun 12 (3) : 747-763    

12. Luo X#, Zheng E#, Wei L, Zeng H, Qin H, Zhang X, Liao M, Chen L, Zhao L, Ruan XZ, Yang P*, Chen Y*. The fatty acid receptor CD36 promotes HCC progression through activating Src/PI3K/AKT axis-dependent aerobic glycolysis. Cell Death Dis. 2021 Mar 26;12(4):328.

13. Luo X#, Li Y#, Yang P, Chen Y, Wei L, Yu T, Xia J, Ruan XZ, Zhao L*,Chen Y*. Obesity Induces Preadipocyte CD36 Expression Promoting Inflammation via the Disruption of Lysosomal Calcium Homeostasis and Lysosome Function. EBioMedicine. 2020 Jun 6;56:102797.

14. Yang P#, Zeng H#, Tan W, Luo X, Zheng E, Zhao L, Wei L, Ruan XZ*, Chen Y*, Chen Y*. Loss of CD36 impairs hepatic insulin signaling by enhancing the interaction of PTP1B with IR. FASEB J. 2020 Apr;34(4):5658-5672.

15. Li Y, Yang P, Zhao L, Chen Y, Zhang X, Zeng S, Wei L, Varghese Z, Moorhead JF, Chen Y*, Ruan XZ*. CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway. J Lipid Res. 2019 Apr;60(4):844-855.

16. Li D#, Chen A#, Lan T#, Zou Y, Zhao L, Yang P, Qu H, Wei L, Varghese Z, Moorhead JF, Chen Y*, Ruan XZ*. SCAP knockdown in vascular smooth muscle cells alleviates atherosclerosis plaque formation via up-regulating autophagy in ApoE-/- mice. FASEB J. 2019 Mar;33(3):3437-3450

17. Yang P#, Su C#, Luo X#, Zeng H, Zhao L, Wei L, Zhang X, Varghese Z, Moorhead JF, Chen Y*, Ruan XZ*. Dietary oleic acid-induced CD36 promotes cervical cancer cell growth and metastasis via up-regulation Src/ERK pathway. Cancer Lett. 2018 Dec 1;438:76-85.  

18. Zhao L, Zhang C, Luo X, Wang P, Zhou W, Zhong S, Xie Y, Jiang Y, Yang P, Tang R, Pan Q, Hall AR, Luong TV, Fan J, Varghese Z, Moorhead JF, Pinzani M, Chen Y*, Ruan XZ*.CD36 palmitoylation disrupts free fatty acid metabolism and promotes tissue inflammation in non-alcoholic steatohepatitis. J Hepatol. 2018 Sep;69(3):705-717.

19. Yang P, Xiao Y, Luo X, Zhao Y, Zhao L, Wang Y, Wu T, Wei L, Chen Y*. Inflammatory stress promotes the development of obesity-related chronic kidney disease via CD36 in mice. J Lipid Res. 2017;58:(7) 1417-1427.

20. Zhong S#, Zhao L#, Wang Y, Zhang C, Liu J, Wang P, Zhou W, Yang P, Varghese Z, Moorhead JF, Chen Y*, Ruan XZ*. Cluster of Differentiation 36 Deficiency Aggravates Macrophage Infiltration and Hepatic Inflammation by Upregulating Monocyte Chemotactic Protein-1 Expression of Hepatocytes Through Histone Deacetylase 2-Dependent Pathway. Antioxid Redox Signal. 2017 Aug 1;27(4):201-214.

21. Chen Y, Zhao L, Li Q, Wheeler DC, Varghese Z, Moorhead JF, Powis SH, Ruan XZ. Inflammatory stress reduces the effectiveness of statins in the kidney by disrupting HMGCoA reductase feedback regulation. Nephrol Dial Transplant. 2014 ;29(10):1864-78

22. Chen Y, Ku H, Zhao L, Wheeler DC, Li LC, Li Q, Varghese Z, Moorhead JF, Powis SH, Huang A*, Ruan XZ*. Inflammatory Stress Induces Statin Resistance by Disrupting 3-Hydroxy-3-Methylglutaryl-CoA Reductase Feedback Regulation. Arterioscler Thromb Vasc Biol. 2014;34:365-376