Institution Address:
Center of Lipid Research
Chongqing Medical University
No.1 Yixueyuan Rd, Yuzhong District
Chongqing, 400016, China
Contact Information:
Tel: 86-23-68802030
Fax: 86-23-68486780
Email: xuemeilian@cqmu.edu.cn
Web: https://lipid.cqmu.edu.cn/
Education:
2002.9–2005.7 Ph.D., Pediatrics, Chongqing Medical University
1999.9–2002.7 M.M. (Master of Medicine), Pediatrics, Chongqing Medical University
1990.9–1995.7 B.Sc, Preventive medicine, Hunan Medical University
Academic Appointments:
1995.7-present Lecturer – Professor, Department of Nutrition and Food Hygiene, School of Public Health, Chongqing Medical University
2011.11-present Professor, Center of Lipid Research, Chongqing Medical School
2015.9-2016.8 Visiting scholar, Department of Environmental Health, University of Cincinnati, Ohio, USA
2010.12-2011.5 Visiting scholar, Lipid Research Unit, Centre for Nephrology, Royal Free Hospital, UCL Medical School, London, UK
2008.11-2010.1 Visiting scholar, Division of Human Genetics, University of Cincinnati, Ohio, USA
2003.3-2005.1 Visiting scholar, Division of Pulmonary Biology, University of Cincinnati, Ohio, USA
Grants:
2020-2023 as Principal Investigator, “Cholesterol metabolites activate LXR pathway and influence lung tumorigenesis”, National Natural Science Foundation of China (NSFC 81973030)
2019 -2022 as Principal Investigator, “The new function of phytosterols in the prevention and treatment of respiratory diseases”, project of Technology Innovation and Application Chongqing, China (cstc2019jscx-msxmX0280)
2019-2020 as Principal Investigator, “Effect of Phytosterols on lung cancer tumorigenesis”, Yihaikerry Nutrition and Food Safety Foundation, Chinese Nutrition Society (CNS-W2018A45)
2013-2015 as Principal Investigator, “Influence of low grade inflammation on cholesterol metabolism in peripheral blood mononuclear cell”, joint project for the Chunhui plan of Ministry of Education, China (Z2012118)
2011-2013 as Principal Investigator, “Influence of high fat diet induced dyslipidemia on susceptibility of lung cancer in mice”, National Natural Science Foundation of China (NSFC 81071907)
2007-2009 as Principal Investigator, “The role of Api6 on macrophage lipid trafficking”, National Natural Science Foundation of China (NSFC 30600660)
Selected Publications:
1. Shi D, Wu J, Wu Y, Lin X, Xu C, Lian X*. High-Fat Diet-Related Obesity Promotes Urethane-Induced Lung Tumorigenesis in C57BL/6J Mice. Front Oncol. 2021; 11: 620993.
2. Wu J, Wu Y, Lian X*. Targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by ER stress and autophagy. Biol Open. 2020; 9(11):bio053298.
3. Gao J, Lin X, He Y, Fu Y, Wu Y, Liao J, Wu Y, Lian X*. The Comparison of Different Obesity Indexes and the Risk of Lung Cancer: A Meta-Analysis of Prospective Cohort Studies. Nutr Cancer. 2019; 71(6):908-921.
4. Lin X, Liu L, Fu Y, Gao J, He Y, Wu Y, Lian X*. Dietary Cholesterol Intake and Risk of Lung Cancer: A Meta-Analysis. Nutrients. 2018; 10(2). pii: E185.
5. Lin X, Lu L, Liu L, Wei S, He Y, Chang J, Lian X*. Blood lipids profile and lung cancer risk in a meta-analysis of prospective cohort studies. J Clin Lipidol. 2017; 11(4):1073-1081.
6. Chen T, Lu L, Xu C, Lin X, Leung YK, Ho SM, Ruan XZ, Lian X*. Inhibition Role of Atherogenic Diet on Ethyl Carbamate Induced Lung Tumorigenesis in C57BL/6J Mice. Sci Rep. 2017; 7(1):4723.
7. Xu C, Zhou L, Lu L, Chen T, Wei S, Lin X, Lian X*. Inflammation has a role in urethane‑induced lung cancer in C57BL/6J mice. Mol Med Rep. 2016; 14(4):3323-8
8. Zhang L, Fang Y, Chen T, Chen K, Lian X*. Role of Api6 in lung inflammation induced by high fat/cholesterol food in C57BL/6J mice. Chinese Journal of Pathophysiology. 2014, 30 (5): 853-858 (Chinese)
9. Chen T, Wang S, Zhang L, Lei X, Wu S, Lian X*. Comparative Study of Lung Cancer Models on BALB/C and C57BL/6J Mice Induced by Multiple Urethane Injections. Sichuan Journal of Zoology. 2014, 33(2): 275-78 (Chinese)
10. Lian X, Yan C, Qin Y, Knox L, Li T and Du H. Neutral Lipids and Peroxisome Proliferator-Activated Receptor-γ Control Pulmonary Gene Expression and Inflammation-Triggered Pathogenesis in Lysosomal Acid Lipase Knockout Mice. Am J Pathol. 2005, 167: 813-821
11. Lian X, Qin Y, Hossain SA, Yang L, White A, Xu H, Shipley JM, Li T, Senior RM, Du H and Yan C. Overexpression of Stat3C in Pulmonary Epithelium Protects against Hyperoxic Lung Injury. The Journal of Immunology. 2005, 174 (11): 7250-7256
12. Yang L, Lian X, Cowen A, Xu H, Du H and Yan C. Synergy between signal transducer and activator of transcription 3 and retinoic acid receptor–αin regulation of the surfactant protein B gene in the lung. Molecular Endocrinology.2004; 18 (6):1520-1532 (co-first author)
13. Lian X, Yan C, Yang L, Xu Y and Du H. Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung. Am J Physiol Lung Cell Mol Physiol. 2004; 286 (4): L801-L807
14. Li T, Qu P, Wang R, Lian X, Mao Ch, and Dai Y. Effect of vitamin A-fortified biscuits on preschool child in Chong Qing, China. SIGHT AND LIFE. NEWSLETTER 2003（1）: 45-49
