Institution Address:
Center of Lipid Research
Chongqing Medical University
No.1 Yixueyuan Rd, Yuzhong District
Chongqing, 400016, China
Contact Information:
Tel: 86-23-68483909
Fax: 86-23-68486780
Email: yinyuanding@cqmu.edu.cn
Web: https://lipid.cqmu.edu.cn/
Education:
2007.9–2010.7 Ph.D., Physiology, Peking University Health Science Center, Beijing, China
2002.9–2005.6 Master of Science, Physiology, Luzhou Medical College, Luzhou, China
1992.9–1995.7 Clinical Medicine, China Three Gorges University,Yichang, China
Academic Appointments:
2019.9-present Distinguish Professor, Center of Lipid Research, Chongqing Medical University ,Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Chongqing, China
2018.9-2019.7 Research Assistant Professor, Department of Molecular Genetics, UT Southwestern Medical Center at Dallas, Dallas, USA
2016.12-2018.8 Instructor, Department of Molecular Genetics, UT Southwestern Medical Center at Dallas, Dallas, USA
2011.7-2016.12 Postdoctoral Researcher, Department of Molecular Genetics, UT Southwestern Medical Center at Dallas, Dallas, USA
2010.7-2011.6 Research Associate, Institute of Myocardium Electrophysiology, Luzhou MedicalCollege, Luzhou, China
2010.7-2011.6 Research Assistant, Institute of Myocardium Electrophysiology, Luzhou MedicalCollege, Luzhou, China
Grants:
2021.1-2021.12 Principal Investigator, “ The role of Asprosin in the development of hepatocellular carcinoma”, Chongqing Municipal Human Resources and Social Security Bureau, cx2020007
2020.10-2023.10 Principal Investigator, “The role of LRP1 in FoxO1-mediated gluconeogenesis and insulin resistance”, Chongqing Science and Technology Bureau, cstc2020jcyj-msxmX0408
2015.2 -2020.1 Participant, “Metabolism of the VLDL receptor and apoE receptor 2 ”, NIH-NHLBI4R37HL063762-16
Selected Publications:
1. Allyson N. Hamlin, Sivaprakasam Chinnarasu, Yinyuan Ding, Xunde Xian, Joachim Herz, Anja Jaeschke, and David Y. Hui. Low density lipoprotein receptor-related protein-1 dysfunction synergizes with dietary cholesterol to accelerate steatohepatitis progression. J Biol Chem. 2018 Jun 22; 293(25):9674-9684
2. Xunde Xian*#, Yinyuan Ding*, Marco Dieckmann*, Li Zhou, Robert E. Hammer, Philippe Boucher, Shirling Tsai and Joachim Herz#. LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis. Elife. 2017 Nov 16;6. pii: e29292. (*, co-first author; #, co-corresponding author)
3. Yinyuan Ding*, Linzhang Huang*, Xunde Xian*, Ivan S. Yuhanna, Catherine R. Wasser, Michael Frotscher, Chieko Mineo, Philip W. Shaul#, and Joachim Herz#. Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial adhesion and lesion macrophage accumulation. Sci Signal., 2016 Mar 15;9(419):ra29. doi: 10.1126/scisignal. aad5578. (*co-first author; #, co-corresponding author)
4. Yinyuan Ding*, Xunde Xian*#, Shirling Tsai and Joachim Herz#. LDL Receptor-Related Protein-1 Protects Against Hepatic Insulin Resistance and hepatic steatosis. EBioMedicine. 2016, 7:135-145 (*co-first author; #, co-corresponding author)
Commented by: Lee Stephen D., Peter Tontonoz. sLRP1ng Up Glucose: LRP1 Regulates Hepatic Insulin Responses.EBioMedicine. 2016, 7:17-18 (doi: 10.1016/j.ebiom.2016.04.002)
5. Erping Yang, Huifeng Zheng, Hao Peng, Yinyuan Ding. Lentivirus-induced knockdown of LRP1 induces osteoarthritic-like effects and increases susceptibility to apoptosis in chondrocytes via the nuclear factor-κB pathway. ExpTher Med., 2015, 10(1):97-105
6. Yinyuan Ding, Ling Zhang, Yuhui Wang, Wei Huang, Yin Tang, Lu Bai, Colin J.D. Ross, Michael R. Hayden, George Liu. Amelioration of hypertriglyceridemia with hypo-alpha-cholesterolemia in LPL deficient mice by hematopoietic cell-derived LPL. PLoS One, 2011,6 (9) :e25620
7. Yinyuan Ding, Yuhui Wang, Hong Zhu, Jianglin Fan, Liqing Yu, George Liu#, Enqi Liu#. Hypertriglyceridemia and delayed clearance of fat load in transgenic rabbits expressing human apolipoprotein CIII. Transgenic Research, 2011, 20 (4): 867-875(#, co-corresponding author)
8. Lu Bai, Yuhui Wang, Yinyuan Ding, Xin Cui, Yin Tang, Wei Huang, Ling Zhang, George Liu. Severe hypertriglyceridemia appears in apolipoprotein CⅢ transgenic mouseChinese Journal of Pathophysiology,2010, 26(11):2235-2239
9. Yinyuan Ding, George Liu. New advancement of genetically manipulated mouse models in dyslipidemia and atherosclerosis. Progress in physiological sciences, 2009, 40(2): 151-153
10. Ling Zhang, Xunde Xian, Yinyuan Ding, George Liu. The effect of bone marrow derived LPL on lipid metabolism in severe lipoprotein lipase deficient hypertriglyceridemic mice. Chin J Arterioscler,2009,17(11):917-919
11. Xiaoqiu Tang, Zhiru Bai, Yinyuan Ding, Yan Yang, Zhifei Liu, Wenjun Huang, Xiaorong Zeng. The detection of the KChIP2 and SK2 gene expression in human atrial myocardium and method research. Sichuan Medical Journal, 2008, 29(7):802-804
12. Yinyuan Ding, Xiaorong Zeng,Yan Yang, Zhifei Liu, Miaoling Li, Wen Zhou, Jie Pei. Effects of Angiotensin II on outward potassium current in human atrial fibrillation. Chinese Journal of Pathophysiology,2007,23(7):1422-1425
13. Yinyuan Ding, Xiaorong Zeng, Yan Yang, Zhifei Liu, Miaoling Li, Wen Zhou, Jie Pei, Xiaoshu Hong. Changes of Ito in human right atrial myocytes with different age or cardiac disease. Chinese Journal of Cardiovascular Review 2006,4(12): 884-887
