Institution Address:

Center of Lipid Research

Chongqing Medical University

No.1 Yixueyuan Rd, Yuzhong District

Chongqing, 400016, China

Contact Information:

Tel:  86-13594012870

Fax: 86-23-68486780

Email: wenquanhu2017@gmail.com, huwenquan2002@163.com

Web: https://lipid.cqmu.edu.cn/

Education:

2009.9–2012.7   Ph.D., Biochemistry and molecular biology, College of life sciences, Nankai University

2006.9–2009.7   Biochemistry and molecular biology, College of life sciences, Nankai University

2002.9–2006.7   B.Sc, Biotechnology, College of life science, Hebei Normal University

Academic Appointments:

2021.9-present   Professor, Center of Lipid Research, Chongqing Medical School

2019.4-2021.8   Instructor, NYU Langone Health, Winthrop Hospital, Obesity and diabetes center, New York University, New York, U.S.A

2017.12-2019.3   Instructor, Department of Surgery, Medical College of Wisconsin, Milwaukee, U.S.A

2012.7-2017.11   Post-doctoral Fellow in the Department of Surgery, Medical College of Wisconsin, Milwaukee, U.S.A

Grants:

2018-2022  as Key Personnel, “Roles of Nogo-B receptor in maintaining the structural integrity of  blood vessels”, NIH/NIDDK, R01HL141733

2017-2022  as Key Personnel, “Role of NgBR in hepatic steatosis”, NIH/NIDDK, R01DK112971

2019-2020  as Key Personnel, “Role of Nogo-B receptor in the pathogenesis of cerebral cavernous  malformation”, AHA Grant-In-Aid, GRNT33671180

2017-2018  as Key Personnel, “High glucose is a risk factor driving the onset of sporadic cerebral cavernous malformation”, Children’s Research Institute Pilot Innovative Research Award

Selected Publications:

1. Zhi Fang, Xiaoran Sun, Xiang Wang, Wenquan Hu*, Qing R. Miao*. The role of histone protein acetylation in regulating endothelial function. Frontiers in cell and developmental biology. 29 April 2021 https://doi.org/10.3389/fcell.2021.672447.

2. Qi Li#, Wenquan Hu#, Yi Chen, Dan Zhao, Shuang Zhang, Zhuo Wei, Xiaoxiao Yang, Yuanli Chen, Xiaoju Li, Chenzhong Liao, Qing R Miao, Jihong Han, Yajun Duan. Nogo-B receptor is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. Journal of Biological Chemistry. 2021 Apr 1;100624. doi: 10.1016/j.jbc.2021.100624. (co-first author)

3. Wenquan Hu#*, Zhong Liu, Valerie Salato, Paula E Nortn , Joyce Bischoff, Suresh N Kumar, Zhi Fang, Sujith Rajan, M Mahmood Hussain, Qing R Miao. NOGOB receptor-mediated RAS signaling pathway is a target for suppressing proliferating hemangioma. JCI Insight. 2021 Feb 8;6(3):e142299. doi: 10.1172/jci.insight.142299.

4. Parchur AK, Fang Z, Jagtap JM, Sharma G , Hansen C , Shafiee S , Hu W , Miao QR , Joshi A . NIR-II window tracking of hyperglycemia induced intracerebral hemorrhage in cerebral cavernous malformation deficient mice. Biomater Sci. 2020 Sep 21;8(18):5133-5144. doi: 10.1039/d0bm00873g. Epub 2020 Aug 21.

5. Yang J, Zeng P, Liu L, Yu M, Su J, Yan Y, Ma J, Hu W, Yang X, Han J, Duan Y, Chen Y. Food with calorie restriction reduces the development of atherosclerosis in apoE-deficient mice. Biochem Biophys Res Commun. 2020 Apr 2;524(2):439-445. doi: 10.1016/j.bbrc.2020.01.109. Epub 2020 Jan 29.

6. Zhang S, Yu M, Guo F, Yang X, Chen Y, Ma C, Li Q, Wei Z, Li X, Wang H, Hu H, Zhang Y, Kong D, Miao QR, Hu W, Hajjar DP, Zhu Y, Han J, Duan Y. Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ 12,14 -PGJ 2 and Nogo. Br J Pharmacol. 2020 Mar;177(5):1041-1060. doi: 10.1111/bph.14886. Epub 2020 Feb 3.

7. Liu T, Wang X, Hu W, Fang Z, Jin Y, Fang X, Miao QR. Epigenetically Down-Regulated Acetyltransferase PCAF Increases the Resistance of Colorectal Cancer to 5-Fluorouracil. Neoplasia. 2019 Jun;21(6):557-570. doi: 10.1016/j.neo.2019.03.011. Epub 2019 Apr 28.

8. Tang J, Guo M, Wang P, Liu J, Xiao Y, Cheng W, Gao J, Hu W, Miao QR. Gd-Metallofullerenol nanoparticles cause intracellular accumulation of PDGFR-α and morphology alteration of fibroblasts. Nanoscale. 2019 Mar 14;11(11):4743-4750. doi: 10.1039/c8nr08667b.

9. Gao P, Wang X, Jin Y, Hu W, Duan Y, Shi A, Du Y, Song D, Yang M, Li S, Han B, Zhao G, Zhang H, Fan Z, Miao QR. Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells. Breast Cancer Res. 2018 Sep 12;20(1):112. doi: 10.1186/s13058-018-1028-5.

10. Ma C, Zhang W, Yang X, Liu Y, Liu L, Feng K, Zhang X, Yang S, Sun L, Yu M, Yang J, Li X, Hu W, Miao RQ, Zhu Y, Li L, Han J, Chen Y, Duan Y. Functional interplay between liver X receptor and AMP-activated protein kinase α inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy. Br J Pharmacol. 2018 May;175(9):1486-1503. doi: 10.1111/bph.14156. Epub 2018 Mar 23.

11. Ying Jin, Wenquan Hu, Tong Liu, Ujala Rana, Irene Aguilera-Barrantes, Amanda Kong, Suresh N Kumar, Bei Wang, Pin Gao, Xiang Wang, Yajun Duan, Aiping Shi, Dong Song, Ming Yang, Sijie Li, Bing Han, Gang Zhao, Zhimin Fan, Qing Robert Miao. Nogo-B receptor increases the resistance of estrogen receptor positive breast cancer to paclitaxel. Cancer Letters. 2018, 419:233-244

12. Baofeng Zhao#, Wenquan Hu#, Suresh Kumar, Patrick Gonyo, Ujala Rana, et al. The Nogo-B receptor promotes Ras plasma membrane translocation and tumorigenesis. Oncogene. 2017, 36, 3406–3416. (co-first author)

13. Wenquan Hu, Wenwen Zhang, Yuanli Chen, Ujala Rana, Ru-jeng Teng, et al. Nogo-B receptor deficiency increases liver X receptor alpha nuclear translocation and hepatic lipogenesis through an adenosine monophosphate-activated protein kinase alpha-dependent pathway. Hepatology. 2016 Nov;64(5):1559-1576.

14. Ujala Rana, Zhong Liu, Suresh N.Kumar, Baofeng Zhao, Wenquan Hu, Michelle Bordas, et al. Nogo-B receptor deficiency causes cerebral vasculature defects during embryonic development in mice. Developmental Biology. 2016, 410(2):190-201.

15. W Zhang, X Wang, W Hu, L Liu, X Li, J Han, Y Chen, Y Duan. Co-treatment of pitavastatin and dexamethasone exacerbates the high fat diet-induced atherosclerosis in apoE deficient mice. Journal of cardiovascular pharmacology. 2015, 6692(2):189-95.

16. Y Chen, Y Duan, X Yang, L Sun, M Liu, Q Wang, X Ma, W Zhang, X Li, Wenquan Hu, Robert Q Miao, Rong Xiang, David P Hajjar, Jihong Han. Inhibition of ERK1/2 and Activation of LXR Synergistically Reduce Atherosclerotic Lesions in ApoE-Deficient Mice. Arteriosclerosis, thrombosis, and vascular biology. 2015, 35 (4), 948-959.

17. Baofeng Zhao#, Bo Xu#, Wenquan Hu#, C Song, F Wang, Z Liu, M Ye, H Zou, QR Miao. Comprehensive proteome quantification reveals NgBR as a new regulator for epithelial– mesenchymal transition of breast tumor cells. Journal of proteomic, 2015, s 112, 38-52. (co-first author)

18. Jiang M, Zhang L, Ma X, Hu W, Chen Y, et al. Tamoxifen inhibits macrophage FABP4 expression through the combined effects of GR and PPARγ pathways. Biochem J. 2013 Sep 15;454(3):467-77. doi: 10.1042/BJ20130580.

19. Ling Zhang, Meixiu Jiang, Yongsheng Shui, Yuanli Chen, Qixue Wang, Wenquan Hu, et al. DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-An LXR-dependent mechanism. BBA-Molecular and Cell Biology of Lipids. 2013, 1831:1134-1145.

20. Chen Y, Duan Y, Kang Y, Yang X, Jiang M, Zhang L, Li G, Yin Z, Hu W, Dong P, et al. Activation of liver X receptor induces macrophage interleukin-5 expression. Journal of Biological Chemistry, 2012, 287(52):43340 -50.

21. Duan Y, Chen Y, Hu W, Li X, et al. PPARg activation and dephosphorylation induce PCSK9 production. Journal of Biological Chemistry, 2012, 287(28):23667-77.

22. Wenquan Hu, Xiaoye Zhou, Meixiu Jiang, Yajun Duan, et al. Statins synergize dexamethasone-induced macrophage fatty acid binding protein expression by a dual glucocorticoid receptor-dependent mechanism. Atherosclerosis, 2012, 222(2):434-443.

23. Hu Wenquan, Li Yaxian, Duan Yajun. ERK1/2 inhibitors reduce adipocyte ap2 protein expression. Acta Scientiarum Naturalium Universitatis Nankaiensis. 2012, 45(1):52-57.

24. Dong P, Xie T, Zhou X, Hu W, Chen Y, et al. Induction of macrophage scavenger receptor type BI expression by tamoxifen and 4-hydroxytamoxifen. Atherosclerosis, 2011, 218(2):435-42.

25. Zhang Rui, Hu Wenquan, Xie Wanqin, Li Cuifeng. Prelimilary Establishment of RNAi-mediated Lipid Transfer Protein Gene CaMBP10 Silencing System in Chinese cabbage. Agricultural Sciences in China，2011, 27(10):168-172.

26. Wenquan Hu, Wanqin Xie, Rui Zhang, Cuifeng Li. JA and Fungal elicitor induce Chinese cabbage CAMBP10 expression. Acta Phytopathologica Sinica, 2009, 39(3):328-332.

27. Wang C, Xie W, Chi F, Hu W, Mao G, et al. BcLTP, a novel lipid transfer protein in Brassica chinensis, may secrete and combine extracellular CaM. Plant Cell Rep. 2008, 27(1):159-169.