Institution Address:

Center of Lipid Research

Chongqing Medical University

No.1 Yixueyuan Rd, Yuzhong District

Chongqing, 400016, China

Contact Information:

Tel: 86-15810911071

Fax: 86-23- 63259631

Email: chenbo31@cqmu.edu.cn

Web: https://lipid.cqmu.edu.cn/

Education:

2018.9–2021.12   Ph.D., Physiology, Peking University

2013.9–2018.7   B.S, Basic medical Science, Peking University

Academic Appointments:

2024.1-present   Special-Term Professor, Centre for Lipid Research & Key Laboratory of Molecular Biology for infectious Diseases (Ministry of Education), Chongqing Medical University

2021.12-2024.1   Assistant Researcher, School of Basic Medical Sciences, Peking University

Grants:

2024-2027  as Principal Investigator, “Mechanistic study of nicotine promoting atherosclerosis by altering bile acid metabolism in intestinal bacteria”, National Natural Science Foundation of China (NSFC 82470480)

2024 -2026  as Principal Investigator, “Study on the mechanism by which nicotine promotes atherosclerosis through intestinal bacteria”, Chongqing Natural Science Foundation

Selected Publications:

1. Bo Chen; Lulu Sun; Guangyi Zeng; Zhe Shen; Kai Wang; Limin Yin; Feng Xu; Pengcheng Wang; Yong Ding; Qixing Nie; Qing Wu; Zhiwei Zhang; Jialin Xia; Jun Lin; Yuhong Luo; Jie Cai;

Kristopher W. Krausz; Ruimao Zheng; Yanxue Xue; Ming-Hua Zheng; Yang Li; Chaohui Yu; Frank J. Gonzalez; Changtao Jiang ; Gut bacteria alleviate smoking-related NASH by degrading gut nicotine, Nature, 2022, 61(7932): 562-568

2. Lulu Sun; Cen Xie; Guang Wang; Yue Wu; Qing Wu; Xuemei Wang; Jia Liu; Yangyang Deng;

Jialin Xia; Bo Chen; Song-Yang Zhang; Chuyu Yun; Guan Lian; Xiujuan Zhang; Heng Zhang; William H. Bisson; Jingmin Shi; Xiaoxia Gao; Pupu Ge; Cui Hua Liu; Kristopher W. Krausz; Robert G. Nichols; Jingwei Cai; Bipin Rimal; Andrew D. Patterson; Xian Wang; Frank J. Gonzalez; Changtao Jiang ; Gut microbiota and intestinal FXR mediate the clinical benefits of metformin, Nature Medicine, 2018, 24(12): 1919-1929

3. Wu, Qing; Sun, Lulu; Hu, Xiaomin; Wang, Xuemei; Xu, Feng; Chen, Bo; Liang, Xianyi; Xia,

Jialin; Wang, Pengcheng; Aibara, Daisuke; Zhang, Shaofei; Zeng, Guangyi; Yun, Chuyu; Yan, Yu; Zhu, Yicheng; Bustin, Michael; Zhang, Shuyang; Gonzalez, Frank J.; Jiang, Changtao ; Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis, JOURNAL OF CLINICAL INVESTIGATION, 2021, 131(9)

4. Xiaopeng Li; Xiujuan Zhang; Jialin Xia; Linqi Zhang; Bo Chen; Guan Lian; Chuyu Yun; Juan

Yang; Yu Yan; Pengcheng Wang; Xuemei Wang; Bo Liu; Huiying Liu; Hui Liang; Yanli Pang; Xian Wang; Changtao Jiang ; Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance, Cell Reports, 2021, 36(8): 109607

5. Bo Chen; Guangyi Zeng; Lulu Sun; Changtao Jiang ; When smoke meets gut: deciphering the interactions between tobacco smoking and gut microbiota in disease development, Science China Life Sciences, 2024